CLINICAL TRIALS AND OBSERVATIONS Age-related Epstein-Barr virus (EBV)–associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients
نویسندگان
چکیده
1Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya; 2Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto; 3Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya; 4Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya; 5Department of Pathology, Saitama Medical Center, Saitama Medical School, Kawagoe; 6Department of Hematology, Nagoya 2nd Red Cross Hospital, Nagoya; 7Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto; 8Department of Pathology, School of Medicine, Kurume University, Kurume; 9Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama; 10Department of Pathology, Tokai University School of Medicine, Isehara; 11Department of Pathology, Teikyo University School of Medicine, Tokyo; 12Department of Microbiology, Kinki University School of Medicine, Osaka; and 13Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Epstein-Barr virus (EBV) load in bone marrow transplant recipients at risk to develop posttransplant lymphoproliferative disease: prophylactic infusion of EBV-specific cytotoxic T cells
A semiquantitative polymerase chain reaction assay was used to monitor the blood levels of Epstein-Barr virus (EBV)DNA in 9 patients receiving allogeneic bone marrow transplants (BMT). Four of 5 recipients of HLA-mismatched T-cell– depleted grafts showed a 4to 5-log increase of EBV-DNA within 1 to 3 months after BMT. Administration of 2 to 4 infusions of 107 EBV-specific cytotoxic Tlymphocytes ...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Loss of circulating CD27 memory B cells and CCR4 T cells occurring in association with elevated EBV loads in XLP patients surviving primary EBV infection
Detailed longitudinal studies of patients with X-linked lymphoproliferative disease (XLP) may increase our understanding of the immunologic defects that contribute to the development of lymphoma and hypogammaglobulinemia in XLP. We describe progressive changes observed in immunoglobulin concentrations, lymphocyte subsets, and Epstein-Barr virus (EBV) loads occurring in a 2-year period in a newl...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France
A national prospective study was designed to collect all cases of lymphoma appearing in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) throughout France over a period of 3 years. A total of 25 cases of lymphoma were recorded, 18 cases of non-Hodgkin lymphoma (NHL), 3 of which were associated with the presence of Epstein-Barr virus (EBV) in lymphoma cells, and 7 cases of...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Prevention of Epstein-Barr virus–lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation
Recipients of a partially T-cell–depleted (TCD) allogeneic stem cell transplantation (allo-SCT) developing reactivation of Epstein-Barr virus (EBV) with quantified viral DNA levels exceeding 1000 genome equivalents/milliliter (geq/mL) are at high risk for EBV–lymphoproliferative disease (EBVLPD). We studied whether preemptive therapy with rituximab prevents EBV-LPD, LPD-mortality, and abrogates...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Treatment of solid organ transplant recipients with autologous Epstein Barr virus–specific cytotoxic T lymphocytes (CTLs)
We have investigated the in vivo safety, efficacy, and persistence of autologous Epstein Barr virus (EBV)–specific cytotoxic T lymphocytes (CTLs) for the treatment of solid organ transplant (SOT) recipients at high risk for EBV-associated posttransplantation lymphoproliferative disease (PTLD). EBV-CTLs generated from 35 patients expanded with normal kinetics contained both CD8 and CD4 lymphocyt...
متن کامل